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Sirtuin Protocol

     

"The lack of food apparently triggers a survival mechanism that helped humans endure times of food scarcity. And along similar lines, intense exercise bouts benefit you by triggering a primal mechanism that enabled early humans to endure extreme physical hardship. These inherent mechanisms are part of the human survival apparatus. When triggered, they help you compensate by increasing energy production efficiency, improving body composition, increasing strength and increasing the capacity to resist fatigue and stress. Your survival requires challenge and action. The biological rule is as plain as it's bold:”   Ori Hofmekler Pro Trainer

"The discovery of metabolic pathways came about from scientists trying to figure out why a calorie-restricted diet increased longevity in organisms pretty much across the board. When the body thinks it is starving, it triggers innumerable processes including turning metabolic pathways on and off. There are many pathways, and new ones being discovered all the time, but the big three are gene/protein combinations called AMPK, sirtuins and mTOR. AMPK is called the body’s “metabolic master switch,” and it maintains energy homeostasis by regulating the energy flow. There are seven members of the sirtuin family, and they sense the environment and alter the metabolism to promote survival. In part, they accomplish this by activating AMPK. The sirtuin family is dependent on the coenzyme NAD+ (nicotinamide adenine dinucleotide), which our bodies produce less of as we age. mTOR (mammalian or mechanistic target of rapamycin regulates growth and development, which is great when you are young. But as you age, excess mTOR activity contributes to inflammation and its numerous problems."   Dr. Sandra Kaufmann The Science of Slowing Aging

"NAD+ declines with age because an enzyme in inflammatory cells that destroys NAD+ increases with age.25 Reducing inflammation, inhibiting the inflammatory enzyme, and replacing NAD+ by supplementing with substances (such as nicotinamide riboside) that lead to NAD+ formation, can restore the benefits of sirtuin and NAD+ (improved insulin sensitivity, mitochondrial function, and DNA repair).25 Moreover, NAD+ restoration rejuvenates stem cells, improving the regenerative capacity of organs and tissues."   Sirtuins and NAD+ for Rejuvenation

"Resveratrol supplied sirtuins can stabilize chromosomes and DNA molecules, preventing breaks and damage that can lead to cancer, they promote DNA repair and they regulate genetic functions that in turn control every activity in the living cell."    Life Extension   Note this is EXACTLY what we want, take your Resveratrol/Grape Seed Extract DAILY

"Resveratrol can increase beneficial apoptosis to facilitate the healthy removal of decrepit cells.13 Resveratrol was shown to induce a critical cellular process called autophagy that removes waste (damaged proteins and organelles) from inside the cell. In a recent study, rats were given the toxic chemotherapy drug doxorubicin (Adriamycin®). Resveratrol, along with calorie restriction, was shown to inhibit the damage done to the hearts of these rats by inducing autophagy resulting in improved cellular waste removal. There is growing evidence that compounds like resveratrol can shield against chemotherapy-induced cellular damage.14,15 "   New Research on Resveratrol   Note apoptosis and autophagy are important mechanisms to prevent cancer and other diseases

"For resveratrol users, NAD+ is especially important. That’s because resveratrol promotes expression of cell proteins called sirtuins that protect against age-related decline.3-7 But sirtuins need NAD+ to function. And as we age, NAD+ levels drastically plummet. 6-8 The result is loss of cellular functions and potential accelerated aging. A patented supplement called nicotinamide riboside replenishes cellular NAD+. Studies reveal how restoring NAD+ may slow or halt certain aging processes, boost brain function, and reduce risk for age-related disorders.3,7,9 "   Power a Longer Life via NAD+ Restoration

"Aging consists of seven categories of things that happen to your cells. No. 1: Changes to DNA, including epigenetic modification and telomere length. No. 2: Disruptions in energy production due to mitochondria failure. No. 3: Problems with metabolic pathways, especially the sirtuins, AMPK, and mTOR pathways. No 4: Quality control problems that affect DNA and protein repair. No. 5: Inflammatory issues due to a faulty immune system. No. 6: Not fulfilling the needs of specific cells. No. 7: Incomplete waste management. To defeat aging, or decelerate the process, you have to take into consideration each of the seven categories."   Dr. Sandra Kaufmann The Science of Slowing Aging

"NAD+ is a coenzyme found in all living cells. It is essential for energy production and DNA repair. In 2014, we introduced a NAD+ precursor called nicotinamide riboside.4 When you take nicotinamide riboside, it converts to NAD+ in your cells, where it facilitates regenerative processes. The most important NAD+ benefit is promoting rapid DNA repair and fueling beneficial longevity proteins. Resveratrol favorably enhances the activation of cellular sirtuin proteins.8 NAD+ is required for our sirtuins to function. As we age, NAD+ levels plummet, which impedes the ability of resveratrol to deliver its benefits."   New Resveratrol and NAD+ Suggestions Kaufmann The Science of Slowing Aging

"The most effective way to boost NAD+ levels in the body is through a newly discovered form of vitamin B3 called nicotinamide riboside.10 Studies have shown that nicotinamide riboside switches “off” the genes of aging, extends life span, increases endurance, improves cognitive function, activates beneficial sirtuins, and enhances cellular energy.5,11 "   Nicotinamide Riboside Boosts NAD+

"Resveratrol favorably enhances the activation of cellular sirtuin proteins.8 NAD+ is required for our sirtuins to function. As we age, NAD+ levels plummet, which impedes the ability of resveratrol to deliver its benefits."   New Resveratrol and NAD+ Suggestions

"Sirtuin activators that are hundreds of times more powerful than resveratrol increase insulin sensitivity, and have therefore been proposed as a treatment for type II diabetes.21 Powerful sirtuin-activators have also been shown to improve the general health and lifespan of mice fed a normal diet.22 Sirtuins can rejuvenate cells by stimulating the recycling of damaged cellular components (autophagy). Sirtuins require the substance NAD+ to function. Sirtuins are important for DNA repair and for efficient function of the energy-producing cellular organelles, mitochondria."   Sirtuins and NAD+ for Rejuvenation

Sirtuins. NDA+, resveratrol, mitochondrial function, autophagy, apoptosis, energy and DNA are part of the somewhat complicated cellular and body rejuvenation  process. If you want to function well in your sixties, seventies, eighties and later you will take the time to discover these details of optimally healthy aging. Do this in your forties or fifties.

How Sirtuins are Produced

"The lack of food apparently triggers a survival mechanism that helped humans endure times of food scarcity. And along similar lines, intense exercise bouts benefit you by triggering a primal mechanism that enabled early humans to endure extreme physical hardship. These inherent mechanisms are part of the human survival apparatus. When triggered, they help you compensate by increasing energy production efficiency, improving body composition, increasing strength and increasing the capacity to resist fatigue and stress. Your survival requires challenge and action. The biological rule is as plain as it's bold:”   Ori Hofmekler Pro Trainer

Very simplistically put it works like this. When your body undergoes severe prolonged STRESS such as prolonged strenuous EXERCISE and or FASTING your body produces Sirtuins. These sirtuins with the help of NAD+ will work in many ways to make your body more efficient and can extend your healthy lifespan.

Among the various ways this happens is improved DNA maintenance, improved cellular maintenance, to include improved Autophagy and improved Apoptosis and improved cellular energy delivery with among other mechanisms AMPK and mTOR.  Read the above referenced work Dr. Sandra Kaufmann The Science of Slowing Aging .

      

Resveratrol Also Boosts Sirtuins

"Resveratrol favorably enhances the activation of cellular sirtuin proteins.8 NAD+ is required for our sirtuins to function. As we age, NAD+ levels plummet, which impedes the ability of resveratrol to deliver its benefits."   New Resveratrol and NAD+ Suggestions

"Resveratrol supplied sirtuins can stabilize chromosomes and DNA molecules, preventing breaks and damage that can lead to cancer, they promote DNA repair and they regulate genetic functions that in turn control every activity in the living cell."    Life Extension   Note this is EXACTLY what we want, take your Resveratrol/Grape Seed Extract DAILY

"NAD+ is a coenzyme found in all living cells. It is essential for energy production and DNA repair. In 2014, we introduced a NAD+ precursor called nicotinamide riboside.4 When you take nicotinamide riboside, it converts to NAD+ in your cells, where it facilitates regenerative processes. The most important NAD+ benefit is promoting rapid DNA repair and fueling beneficial longevity proteins. Resveratrol favorably enhances the activation of cellular sirtuin proteins.8 NAD+ is required for our sirtuins to function. As we age, NAD+ levels plummet, which impedes the ability of resveratrol to deliver its benefits."   New Resveratrol and NAD+ Suggestions Kaufmann The Science of Slowing Aging

"For resveratrol users, NAD+ is especially important. That’s because resveratrol promotes expression of cell proteins called sirtuins that protect against age-related decline.3-7 But sirtuins need NAD+ to function. And as we age, NAD+ levels drastically plummet. 6-8 The result is loss of cellular functions and potential accelerated aging. A patented supplement called nicotinamide riboside replenishes cellular NAD+. Studies reveal how restoring NAD+ may slow or halt certain aging processes, boost brain function, and reduce risk for age-related disorders.3,7,9 "   Power a Longer Life via NAD+ Restoration

"Resveratrol can increase beneficial apoptosis to facilitate the healthy removal of decrepit cells.13 Resveratrol was shown to induce a critical cellular process called autophagy that removes waste (damaged proteins and organelles) from inside the cell. In a recent study, rats were given the toxic chemotherapy drug doxorubicin (Adriamycin®). Resveratrol, along with calorie restriction, was shown to inhibit the damage done to the hearts of these rats by inducing autophagy resulting in improved cellular waste removal. There is growing evidence that compounds like resveratrol can shield against chemotherapy-induced cellular damage.14,15 "   New Research on Resveratrol   Note apoptosis and autophagy are important mechanisms to prevent cancer and other diseases

"The problem stumped scientists for years: How to “wake up” sleeping sirtuin genes (without caloric restriction)… Now we know these genes can be awakened and called upon to change your body in the course of a single lifetime – safely and naturally. You don’t have to starve yourself to switch on your longevity gene. You can activate it with a simple nutrient. It’s called resveratrol. Resveratrol shifts your cells into high gear, stimulating them to perform a variety of activities that promote health and longevity.” Doctor Al Sears MD, Note the sirtuin gene extends lifespan

Resveratrol (Grape Seed Extract) is a simple supplement which has been shown to have MANY health benefits. I have taken GSE for many decades; I identified GSE as an important antioxidant I wanted to ingest each and every day. It turns out this was a very important decision. Resveratrol and Grape Seed Extract, the non-patented name for Resveratrol, is one way to increase the extremely important Sirtuins. You definitely want a good sirtuin level in your body.

    

NAD+ is REQUIRED for Sirtuin Functioning

"Resveratrol favorably enhances the activation of cellular sirtuin proteins.8 NAD+ is required for our sirtuins to function. As we age, NAD+ levels plummet, which impedes the ability of resveratrol to deliver its benefits."   New Resveratrol and NAD+ Suggestions

"Sirtuins require the substance NAD+ to function. Sirtuins are important for DNA repair and for efficient function of the energy-producing cellular organelles, mitochondria."   Sirtuins and NAD+ for Rejuvenation

"NAD+ declines with age because an enzyme in inflammatory cells that destroys NAD+ increases with age.25 Reducing inflammation, inhibiting the inflammatory enzyme, and replacing NAD+ by supplementing with substances (such as nicotinamide riboside) that lead to NAD+ formation, can restore the benefits of sirtuin and NAD+ (improved insulin sensitivity, mitochondrial function, and DNA repair).25 Moreover, NAD+ restoration rejuvenates stem cells, improving the regenerative capacity of organs and tissues."   Sirtuins and NAD+ for Rejuvenation

"The most effective way to boost NAD+ levels in the body is through a newly discovered form of vitamin B3 called nicotinamide riboside.10 Studies have shown that nicotinamide riboside switches “off” the genes of aging, extends life span, increases endurance, improves cognitive function, activates beneficial sirtuins, and enhances cellular energy.5,11 "   Nicotinamide Riboside Boosts NAD+

"NAD+ is a coenzyme found in all living cells. It is essential for energy production and DNA repair. In 2014, we introduced a NAD+ precursor called nicotinamide riboside.4 When you take nicotinamide riboside, it converts to NAD+ in your cells, where it facilitates regenerative processes. The most important NAD+ benefit is promoting rapid DNA repair and fueling beneficial longevity proteins. Resveratrol favorably enhances the activation of cellular sirtuin proteins.8 NAD+ is required for our sirtuins to function. As we age, NAD+ levels plummet, which impedes the ability of resveratrol to deliver its benefits."   New Resveratrol and NAD+ Suggestions Kaufmann The Science of Slowing Aging

"For resveratrol users, NAD+ is especially important. That’s because resveratrol promotes expression of cell proteins called sirtuins that protect against age-related decline.3-7 But sirtuins need NAD+ to function. And as we age, NAD+ levels drastically plummet. 6-8 The result is loss of cellular functions and potential accelerated aging. A patented supplement called nicotinamide riboside replenishes cellular NAD+. Studies reveal how restoring NAD+ may slow or halt certain aging processes, boost brain function, and reduce risk for age-related disorders.3,7,9 "   Power a Longer Life via NAD+ Restoration

Please consider NAD+ and its chief nutrient nicotinamide riboside as an integral part of the cellular rejuvenation process centering on Sirtuins. You must assure NAD+ to gain the many benefits of Sirtuins; it becomes increasingly difficult to assure NAD+ as we grow older. IMO supplementing with nicotinamide riboside is REQUIRED once you hit sixty or so.

     

Sirtuins and DNA

"Resveratrol supplied sirtuins can stabilize chromosomes and DNA molecules, preventing breaks and damage that can lead to cancer, they promote DNA repair and they regulate genetic functions that in turn control every activity in the living cell." Life Extension   Note this is EXACTLY what we want, take your Resveratrol/Grape Seed Extract DAILY

"Sirtuins are important for DNA repair and for efficient function of the energy-producing cellular organelles, mitochondria."   Sirtuins and NAD+ for Rejuvenation

As we grow older our repair and maintenance or our DNA becomes ever more important. Sirtuin activated DNA maintenance can help in this important task.

      

Sirtuins and Autophagy

"Sirtuin activators that are hundreds of times more powerful than resveratrol increase insulin sensitivity, and have therefore been proposed as a treatment for type II diabetes.21 Powerful sirtuin-activators have also been shown to improve the general health and lifespan of mice fed a normal diet.22 Sirtuins can rejuvenate cells by stimulating the recycling of damaged cellular components (autophagy). Sirtuins require the substance NAD+ to function. Sirtuins are important for DNA repair and for efficient function of the energy-producing cellular organelles, mitochondria."   Sirtuins and NAD+ for Rejuvenation

"NAD+ declines with age because an enzyme in inflammatory cells that destroys NAD+ increases with age.25 Reducing inflammation, inhibiting the inflammatory enzyme, and replacing NAD+ by supplementing with substances (such as nicotinamide riboside) that lead to NAD+ formation, can restore the benefits of sirtuin and NAD+ (improved insulin sensitivity, mitochondrial function, and DNA repair).25 Moreover, NAD+ restoration rejuvenates stem cells, improving the regenerative capacity of organs and tissues."   Sirtuins and NAD+ for Rejuvenation

Sirtuins help activate and guide the Autophagy process.

Sometimes a cell has a minor flaw and can be saved if the flaw can be removed, autophagy is one way. Autophagy removes slightly damaged organelles and damaged proteins; recycling them within the cell if possible. This allows the cell to function as well as a younger cell. Your cells being damaged or encumbered with poorly functioning components is an important part of GROWING OLDER.

     

Stress and Sirtuins

Stress of any sort can increase your Sirtuins. Suppose you are having problems with your Job or Spouse, instead of pure gloom try to take it in stride. Most any problem can be made better with some good effort; almost all problems with your spouse can be made better with a little thought and placing yourself in THEIR SHOES.

In the meantime while under the stress this problem(s) engender KNOW it is helping as well as hurting.

    

How to Boost Sirtuins

  • Stress   yes here is a good stress result

  • NAD+   does not produce but UNLOCKS sirtuins and is thus REQUIRED

  • Strenuous Prolonged Exercise   How do you not feel GOOD busting your ass for good health?

  • Fasting   What a glorious REQUIRED good health practice

  • Resveratrol   can produce Sirtuins

  • Resveratrol and/or the poor man's Resveratrol Grape Seed Extract   can produce Sirtuins

  • Grape Seed Extract   can produce Sirtuins

  • OPCs   can possibly help since both resveratrol and grape Seed Extract are OPCs IMO there is a good chance the OPCs MAY help. in any case the super salubrious OPCs cannot hurt

      

Bottom Line:

IMO make it a priority to get the Healthspan elongating Sirtuins WORKING to LENGTHEN your HEALTHY old age and your HEALTH at any age. At eighty I can tell you getting old is not so bad as long as you CAN DO most everything you want to do. Yeah you have to do it more slowly than at twenty; not always a bad thing.

 

 

 

 

 

 

 

 

 

This File was last updated on 26 February 2019 02:57 PM

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