Arterial Plaque Protocol

    

BOTTOM LINE: Please take at least about three grams of vitamin C per day, assure you eat NO supermarket oils or junk food and eat fresh and you will obviate most arterial plaque

   

"What if you were to learn that every day, 25 percent of your calories came from a poison, disguised as a food? And what if you discovered that this chemical imposter was responsible for your insulin resistance and weight gain? And elevated blood pressure. And elevated triglycerides and LDL. And depletion of vitamins and minerals. And even gout, heart disease and liver damage? What if you were to discover that this toxic substance had been dumped into your food in gradually increasing quantities for the last thirty years, with the full knowledge and blessings of the American Heart Association, the American Medical Association, the USDA and the FDA?      Doctor Robert H. Lustig MD  UCSF        Start of series, NOTE You MUST watch this nine part series This video will help you kick the deadly sugar habit, Please start your anti-plaque program by eliminating sugar/HFCS from your diet.

"The important thing is not to stop questioning. Curiosity has its own reason for existing. One cannot help but be in awe when he contemplates the mysteries of eternity, of life, of the marvelous structure of reality. It is enough if one tries merely to comprehend a little of this mystery everyday. Never lose a holy curiosity."  Albert Einstein, Note applied to medicine Einstein is saying Clinical Experience trumps Medical Dogma every time, if the clinic disagrees with the dogma THROW the dogma, The corrupt establishment will not do this but we MUST

"If God didn’t make it; don’t eat it.” Doctor Robert Rowen MD

“The discovery of the vulnerable plaque is an astonishing new breakthrough in cardiac research and explains why there has never been a significant reduction in heart attacks or deaths in surgical patients. It also lends itself to a kinder, non-invasive, supplement-based protocol that can give men and women immediate protection against heart attacks and strokes.” Doctor Garry F. Gordon, MD, DO

“The frequency of the arterial plaque pathomechanism today is directly related to its efficacy as a defense mechanism during the evolution of man, particularly in stabilizing the vascular wall during ascorbate deficiency.” Doctor Matthias Rath

“My discovery of the Ice Age - vitamin deficiency - cardiovascular disease connection will eventually lead to the eradication of heart attacks, strokes and related cardiovascular diseases.” Doctor Matthias Rath

“If benign materials such as vitamin C are available to repair the injured artery the need for lipoprotein(a) is moot. Without adequate amounts of vitamin C lipoprotein(a) becomes indispensable.”  Doctor Matthias Rath

“The deposition of lipoprotein(a) in the form of largely intact particles implies the reversibility of the arterial plaque mechanism.”  Doctor Matthias Rath

“Lioprotein(a) is ten times more dangerous than LDL.” Doctor Matthias Rath

“Scurvy must have killed many, many people during the ice ages when vitamin C was almost impossible to obtain in quantities sufficient for health. For the survival of the species it is better to die directly or indirectly of arterial plaque after reproducing than to die of scurvy before we have reproduced. If Doctors Rath and Pauling’s theory is correct they lead the way to cure the most prolific killer in North America for a few pennies of ascorbate a day.” Udo Erasmus commenting on the work of Doctors Matthias Rath and Linus Pauling, Note we are still in the ice ages

“Both garlic and HDL were able to reduce plaque formation and size within 30 minutes of incubation in these experiments. Existing plaques were dissolved by up to 25% within 15 minutes after the garlic was introduced, indicating a reversal of existing problems related to build-up of arterial plaque. In addition, calcification of the cholesterol docking sites in the arteries was reduced by up to 50% in the presence of the garlic extracts.” Professor Guautnter Siegel, M.D., University of Medicine Berlin

“Oxidation of low-density lipoprotein (LDL) is a primary initiating event in the development of atherosclerosis. LDL oxidation occurs when oxidants such as peroxynitrite radical, iron ascorbate, and copper ascorbate modify LDL particles. Once LDL is oxidized, it can no longer be recognized by LDL receptors, but instead is targeted by scavenger receptors on macro-phages, leading to the formation of lipid-filled foam cells observed in atherosclerotic lesions.” Life Extension

“Studies have also shown that Lp(a) holds fast to damaged blood vessel, attracting other Lp(a) molecules, and finally constituting the atherosclerotic plaques. In fact, a high Lp(a) level (more than 30 mg/dl) has been revealed to carry a 10 times greater risks for heart disease than LDL cholesterol level.” Doctor Michael Lam MD

“Circling the world in the 1920s and 30s, Doctor Price and his wife found the same sinister pattern among “primitive” populations, whether isolated Irish fishermen, tribal Africans, Pacific Islanders, Eskimos, North and South American Indians or Australian Aborigines. Those groups that followed their traditional nature-based diets enjoyed good health and vigor and those that turned to the ‘civilized’ diet of processed, sugar-laden foods soon developed a variety of ills, including misshapen bones and teeth-and the situation worsened with each generation.” Doctor Robert M. Cathcart MD

“Vitamin E prevents white blood cells from adhering to the artery wall, thus a primary step in arterial closing has been averted.” Devaraj et al 2000

"HDL particles seek out LDL within the artery walls and act like straws, sucking out the cholesterol and transporting it to the liver for disposal. HDL also has important antioxidant and anti-inflammatory functions." Doctor Michael Ozner MD

"What makes high levels of triglycerides so dangerous is their shrinking of the average LDL particle size, making the LDL more likely to enter the artery wall and possibly begin the atherosclerosis process." Doctor Michael Ozner MD

"The amino acids L-lysine and L-proline competitively interfere with the binding of lipoprotein(a) to constituents of the vascular wall and atherosclerotic lesions. The therapeutic use of these amino acids could prevent further buildup of lipoprotein(a) accumulation in the vascular wall. More importantly, optimum concentrations of L-lysine and L-proline could release deposited lipoprotein(a) but also other atherogenic lipoproteins form the vascular wall." Doctor Matthias Rath

"Excessive clotting and vascular disease resulting from high levels of lipoprotein (a) can be reversed by iodine treatment.”   Doctor James Howenstine, MD

"Nicotinic acid (Niacin) is the most potent treatment clinically available for lowering LDL and VLDL and raising HDL."  Digby

"Niacin raises HDL levels which promotes removal of cholesterol from blood vessel walls. Niacin also mediates anti-inflammatory effects in blood vessel walls." Life Extension

"A growing number of scientists believe macular degeneration is related to to slow degradation of blood vessels in the eye. It may be that increased levels of homocysteine causes vascular endothelial injury by promoting free radical release."   Life Extension

"A rich source of flavonoids cranberries are also arousing interest for their potential to reduce the formation of arterial plaque."   Life Extension

"What if you were to learn that every day, 25 percent of your calories came from a poison, disguised as a food? And what if you discovered that this chemical imposter was responsible for your insulin resistance and weight gain? And elevated blood pressure. And elevated triglycerides and LDL. And depletion of vitamins and minerals. And even gout, heart disease and liver damage? What if you were to discover that this toxic substance had been dumped into your food in gradually increasing quantities for the last thirty years, with the full knowledge and blessings of the American Heart Association, the American Medical Association, the USDA and the FDA?      Doctor Robert H. Lustig MD  UCSF        Start of series, NOTE You MUST watch this nine part series

"The study also found that cholesterol esters (chemically attached fatty acid structures) are the predominant lipid fraction in all plaque types, and that both cholesterol and polyunsaturated fatty acids (PUFAs), in particular, abundant parent omega-6, may form oxidized derivatives that are toxic to most types of arterial cells. Most interesting is the conclusion that arterial plaque rupture, which can cause thrombosis and vessel occlusion and increase the potential for myocardial infarction and stroke, was significantly related to oxidation of the LA.”     Brian Peskin PhD, Excellent Article on Atherosclerosis , Note LA is omega 6

“The mice supplemented with folic acid had a higher ratio of reduced glutathione to oxidized glutathione. Reduced glutathione is your body's premier detoxifier and free radical scavenger. The researchers also found that folic acid participates in the all-important nitric oxide pathway. Nitric oxide is the chemical that dilates your arteries, keeping them healthy. And, finally, they said that folic acid helps regulate insulin and cellular stress responses.”   Doctor Robert Rowen M

    

For more Research on Arterial Plaque (See Arterial Plaque Research Section)

    

Atherosclerosis

"Atherosclerosis is the result of injury to the extremely thin layer of endothelial cells that line the inside surface (the lumina) of the heart and blood vessel walls. Circulatory toxins such as smoke, free radicals, sugar and infection cause these injuries. Numerous established studies have confirmed that an impaired endothelial function is linked to all major coronary heart diseases." Doctor Michael Lam MD, Note here is the key initiating event, prevent this injury and you prevent much CVD

"Gerhard Spiteller, who has investigated EFAs and their degradation products—specifically, the influence of these substances in mammalian physiology—concluded that consumption of oxidized PUFA-cholesterol esters is responsible for the initial damage to endothelial cells and that cholesterol oxidation products are incorporated into LDL-C in the liver. LDL carries these toxic compounds into the endothelial walls where they cause cell damage, and thus injury is not caused by an increase in free cholesterol but by an increase in oxidized cholesterol esters."   Brian Peskin PhD, Note at last the proof cholesterol is innocent it is the cholesterol esterified with the denatured omega 6s that is the bad actor

"Irrespective of the pathomechanisms of human atherogenesis they can largely be prevented by maintaining the structural integrity, stability, and elasticity of the vascular wall." Doctor Matthias Rath, Note here it is keep your arteries healthy and you will NEVER have to deal with arterial plaque

All of the current theories of atherogenesis posit some form of LDL particle entering the dysfunctional arterial wall. As Doctor Rath states above if we keep this from happening there will be no atherosclerosis. Vitamin C, vitamin E, omega EFAs, collagen, other antioxidants and preventing successful attacks on the vascular wall are the means to keep our vascular walls intact. 

    

IMO a simple three pronged approach may prevent much CVD

"Ascorbate deficiency is an important underlying factor and that all mechanisms known today leading to CVD can be triggered by ascorbate deficiency."   Doctor Matthias Rath, Note ascorbate is vitamin C in it's complete form as found in nature, ascorbic acid is a component of ascorbate

“If we do not have sufficient amounts of Vitamin C to effect a constant intracellular concentration, then oxidized LDL and Lp(a) will further attract other oxidized lipids, thus resulting in plaque formation over time. To prevent this, we must flood our bodies with an abundant supply of Vitamin C and E.” Doctor Michael Lam M

“The fatty acids found in artery clogs are mostly unsaturated (74%) of which 41% are polyunsaturated.” Lancet 1994 344:1195

“Animal fats contain many nutrients that protect against cancer and heart disease; elevated rates of cancer and heart disease are associated with consumption of large amounts of vegetable oils.” Fed Proc July 1978 37:2215

“Certain foods contain free radicals which, when eaten, enter the body and damage it. The major sources of dietary free radicals are chemically-altered fats from commercial vegetable oils, vegetable shortening and all oils heated to very high temperatures.” Stephen Byrnes

“Vegetable oil is truly an "external factor", something in our environment that has changed dramatically in the last 100 years (as opposed to our genes, which are essentially the same). A century ago, nearly all fats eaten in the U.S. came from animals. That's how it's been for humans since the beginning of time, with the exception of seasonal nuts and oily seeds for some groups. Polyunsaturated fat (PUFA) consumption in the US has more than tripled in the last 100 years, with the increase coming almost solely from omega-6 linoleic acid-rich seed oils like soybean and corn oil.” Blogger Stephan

“Doctor Willis found that people taking 1,500mg of vitamin C a day for 12 months reversed plaque while those who didn't take vitamin C had worsening plaque. When you lack vitamin C, cracks and lesions form in the walls of your blood vessels. When blood vessels break down, arterial plaques fortify the weakness and "repair" the damage. But when these arterial plaques become too thick, they block the flow of blood. And a lack of blood to the heart triggers a heart attack - and a lack of blood to the brain causes a stroke.”    Doctor Al Sears MD

   

IMO a simple three pronged approach may prevent much CVD

Vitamin C

"A high Lp(a) level (more than 30 mg/dl) has been revealed to carry a 10 times greater risks for heart disease than LDL cholesterol level.” Doctor Michael Lam MD, Note Lp(a) ONLY becomes elevated when you have let your vitamin C levels fall.

1) You must take at least 3 grams of vitamin C/day (See Vitamin C Protocol) as supplemental vitamin C and get all the ascorbate, natural vitamin C, from your food as you can. Raw food is best as vitamin C is destroyed by heat.

Processed Vegetable Oil

"Elevated rates of cancer and heart disease are associated with consumption of large amounts of vegetable oils.” Fed Proc July 1978 37:2215, Note these processed vegetable oils yield denatured omega-6 EFAs.

2) You must totally avoid denatured Omega EFAs found largely as denatured Omega 6 EFAs in processed vegetable oil (See Polyunsaturated  Oils Protocol). Junk food is often made from this denatured processed vegetable oil or it's hydrogenated siblings.

Homocysteine

"Homocysteine is a naturally occurring amino acid. But too much of it irritates the lining of your blood vessels and prevents them from dilating. This increases your risk of heart attack and stroke. One study found that levels of homocysteine were dramatically higher in men who died from heart attacks. They discovered that men with high homocysteine levels were four times more likely to suffer a fatal heart attack than those with lower levels."   Doctor  Al Sears MD, Note it is homocysteine NOT cholesterol that is a major CVD problem

3) You must avoid all (Homocysteine) lingering in your blood. This is rather easy to do and is salubrious for MANY body processes beyond arterial plaque formation. Basically all you must do is insure you ingest the complete (Vitamin B Complex) every day.

What is Disease?    

     

How the Initial Break in the Artery Wall is Facilitated

"What if the cholesterol structure in the arterial intima contained significant amounts of oxidized or nonfunctional parent omega-6 attributable largely to ingestion of foods containing LA oxidized or otherwise damaged in the course of routine food processing, before any in vivo oxidation? We know that the intima consists of a single layer of endothelial cells containing significant LA, but no ALA. Consumed, processed LA deposited in arterial intimal cell membranes leads to abnormal oxidation at the vascular injury site, thus causing injurious inflammation. In this case, abnormal oxidation involves formation of a hydroperoxide from LA. What else could cause LA in the endothelial cells to become oxidized? Could significant amounts of LA already defective from routine food processing transported by LDL-C be the real culprit?" Brian Peskin PhD, Note LA is omega 6 EFA. IMO Brian has nailed the initial break in the endothelial layer it is often from the processed defective vegetable oil we are consuming by the 100,000 of tons. The endothelial cells are constructed with this inferior fat. Thank you Brian you have done what 100s of Billions of "Research" could not or was not allowed to do

“Animal fats contain many nutrients that protect against cancer and heart disease; elevated rates of cancer and heart disease are associated with consumption of large amounts of vegetable oils.” Fed Proc July 1978 37:2215, Note these processed vegetable oils yield denatured omega-6 EFAs.

"AA (arachadonic acid) is a critical omega-6 derivative and major biochemical component which occurs in virtually every cell we have. It is the building block of the most potent anti-aggretory (“helps blood thinning”) agent known, termed prostacyclin. AA also inhibits platelet adhesion making it a natural “blood thinner.” AA even helps SOLVE vascular problems as a response to injury."   Brian Peskin PhD

"Gerhard Spiteller, who has investigated EFAs and their degradation products—specifically, the influence of these substances in mammalian physiology—concluded that consumption of oxidized PUFA-cholesterol esters is responsible for the initial damage to endothelial cells and that cholesterol oxidation products are incorporated into LDL-C in the liver. LDL carries these toxic compounds into the endothelial walls where they cause cell damage, and thus injury is not caused by an increase in free cholesterol but by an increase in oxidized cholesterol esters."   Brian Peskin PhD, Note at last the proof cholesterol is innocent it is the cholesterol esterified with the denatured omega 6s that is the bad actor

"Homocysteine is a naturally occurring amino acid. But too much of it irritates the lining of your blood vessels and prevents them from dilating. This increases your risk of heart attack and stroke. One study found that levels of homocysteine were dramatically higher in men who died from heart attacks. They discovered that men with high homocysteine levels were four times more likely to suffer a fatal heart attack than those with lower levels."   Doctor  Al Sears MD, Note it is homocysteine NOT cholesterol that is a major CVD problem

"It was also found that cholesterol esters (chemically attached fatty acid structures) are the predominant lipid fraction in all plaque types, and that both cholesterol and polyunsaturated fatty acids (PUFAs), in particular, abundant parent omega-6, may form oxidized derivatives that are toxic to most types of arterial cells. Most interesting is the conclusion that arterial plaque rupture, which can cause thrombosis and vessel occlusion and increase the potential for myocardial infarction and stroke, was significantly related to oxidation of the LA." Brian Peskin PhD            

“Research has demonstrated that homocysteine causes oxidative stress to the vascular endothelium and that maintaining healthy levels of homocysteine is important for heart health.”   Doctor Al Sears MD

"A growing number of scientists believe macular degeneration is related to to slow degradation of blood vessels in the eye. It may be that increased levels of homocysteine causes vascular endothelial injury by promoting free radical release."   Life Extension, Note it is important IMO to remember that your endothelium is part of your smallest micro-arteries

 

IMO it is clear that the (highly processed denatured omega 6 oils) and (Homocysteine)  are the chief culprits in the initial break in the endothiailal cells which start the atherosclerotic process. There are others. Anything causing inflammation may injure the endothiailal cells. Once this break occurs if we do not have enough vitamin C and the other collagen components we will be unable to correctly repair this break. Thus we have begun the process of building arterial plaque.

      

What is Arterial Plaque?

"For decades, saturated fat was incorrectly believed to be the cause of arterial plaque. This is clearly not the case, as identified in a landmark article published in 1994. Investigators found that plaque contained more than 10 different compounds, none of which was related to saturated fat. Other independent investigations confirmed this finding.”   Brian Peskin PhD, Excellent Article on Atherosclerosis , Note LA is omega 6

    

Arterial plaque comes in at least two forms

1)    Hard Arterial Plaque

2)    The Vulnerable Plaque

    

Hard Arterial Plaque

“Lioprotein(a) is ten times more dangerous than LDL.” Doctor Matthias Rath

Just what is hard arterial plaque? This question is important because the answer will clear up several important health concerns. Hard arterial plaque is the term for a condition that usually starts as a small cut to your endothelium which lines your inner artery wall. These cuts occur as a normal part of living, although as we will see the stronger your collagen and better your levels of vitamins C, vitamin E, and omega EFAs the fewer cuts you will probably get. However many of these cuts you get your body must repair them all with the materials YOU have given it for these repairs. If you have plenty of vitamin C and  omega EFAs your body will use them to repair the cut. The repair made will be smooth and in a few days you will not able to tell the cut was ever there. The tissue will be completely healed just as cut on your finger heals with no scar or trace.

If you do not have enough vitamin C your body will use lipoprotein(a) to repair the cut. This cut repair made with lipoprotein(a) is termed an “Atherosclerotic Lesion”.

“Human atherosclerotic lesions are primarily composed of lipoprotein(a)”  Doctor Matthias Rath

A newly formed arterial plaque is primarily composed of lipoprotein(a), immune system proteins and fibrinogen (See Fibrinogen Protocol)/fibrin. Once an arterial plaque has formed lipids including the dreaded LDL  and calcium are attracted and bound into the plaque. Note healthy LDL does not initiate the plaque formation. Mature arterial plaque is composed of 50% calcium, oxidized polyunsaturated fatty acids and 3% lipoprotein(a). Human atherosclerotic lesions are based on lipoprotein(a). Lipoprotein(a) acts as a protective healer for cuts and bruises in the arterial wall most likely weakened by lack of vitamin C and insufficient omega EFAs, just like a scab forms over external cuts.

“Isolated LDL deposition are rarely found in newly formed arterial plaque and LDL alone, without simultaneous lipoprotein(a) deposition, cannot be considered a primary factor determining the advancement of human atherosclerotic lesions.” Doctor Matthias Rath

    

Why is Hard Arterial Plaque required?

"Ascorbate deficiency is an important underlying factor and that all mechanisms known today leading to CVD can be triggered by ascorbate deficiency. The different mechanisms of human CVD known today therefore all compensate for impaired integrity and stability of the vascular wall caused by chronically low dietary ascorbate intake. If these mechanisms overshoot, heart attack, stroke and other forms of CVD develop. "  Doctor Matthias Rath, Note ascorbate is vitamin C in it's complete form as found in nature, ascorbic acid is a component of ascorbate

Lipoprotein(a) is the backup for vitamin C in the repair of your arteries. When your levels of vitamin C drop your levels of lipoprotein(a) grow. Vitamin C leaves an arterial wound repair which is smooth and does not grow. If you do not give your body enough vitamin C, at least about three grams per day to be safe IMO, your body is forced to use lipoprotein(a) to make TEMPORARY repairs of the wounds to your arteries. Which repair would you like?

   

The Temporary arterial wound repair made with lipoprotein(a) is DESIGNED to grow into hard arterial plaque

The hard arterial plaque is a crude plug which keeps you from bleeding to death since you have been foolish enough not to have supplied your body with enough vitamin C. This process is designed to be a TEMPORARY fix and is required because YOU have let your levels of vitamin C drop too low or have otherwise weakened your arteries. You are mandated to ingest LOTS of vitamin C and otherwise assure good collagen (See Collagen Protocol) production and proper sound artery construction SOON.

“If benign materials such as vitamin C are available to repair the injured artery the need for Lp(a) is moot. Without adequate amounts of vitamin C Lp(a) becomes indispensable.”  Doctor Matthias Rath

This temporary repair process can turn into Atherosclerosis IF you do not get your vitamin C levels elevated and otherwise assure good collagen production. Doctor Matthias Rath explains how this process likely evolved as a response to chronic low ascorbate ingestion during early ice ages.

Low ascorbate ingestion during the ice ages past and arterial plaque

    

Lipoprotein(a) has been implicated in these seriously negative health conditions

• Hard Arterial Plaque
• Soft Arterial Plaque
• Atherosclerosis
• Stroke
• Angina Pectoris
• Aortic Stenosis
• Thromboembolism

     

The Vulnerable Plaque

"The progression of atherosclerotic deposits is paralleled by a structural impairment of the vascular wall and by the accumulation of lipoprotein(a)." Doctor Matthias Rath, Note Doctor Rath is telling us there is no fundamental causal difference between hard and soft plaque initiation  

"It was also found that cholesterol esters (chemically attached fatty acid structures) are the predominant lipid fraction in all plaque types, and that both cholesterol and polyunsaturated fatty acids (PUFAs), in particular, abundant parent omega-6, may form oxidized derivatives that are toxic to most types of arterial cells. Most interesting is the conclusion that arterial plaque rupture, which can cause thrombosis and vessel occlusion and increase the potential for myocardial infarction and stroke, was significantly related to oxidation of the LA."    Brian Peskin PhD

In recent years there has been an important cardiovascular discovery called the vulnerable plaque. The vulnerable plaque is a soft counterpart of the hard atherosclerotic plaque we have known about for decades. Vulnerable plaque occurs in the inner surface of your artery and does not block the blood flow thru the artery just as the hard arterial plaque does. Your body treats vulnerable plaque as an infection site and creates a capsule to shield it from the blood flow. If this capsule is ruptured it may help cause a heart attack or stroke. Please note both the hard and soft plaques begin with a small cut to your endothelium which lines your inner artery wall. Both progress when vitamin C and other components of good collagen and endothelial construction are lacking. So we obviate both in the same way. 

     

Continuation of  Arterial Plaque Protocol (See Arterial Plaque Protocol Continuation)