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NAD+ Protocol

     

"NAD+ is a coenzyme found in all living cells. It is essential for energy production and DNA repair. In 2014, we introduced a NAD+ precursor called nicotinamide riboside.4 When you take nicotinamide riboside, it converts to NAD+ in your cells, where it facilitates regenerative processes. The most important NAD+ benefit is promoting rapid DNA repair and fueling beneficial longevity proteins. Resveratrol favorably enhances the activation of cellular sirtuin proteins.8 NAD+ is required for our sirtuins to function. As we age, NAD+ levels plummet, which impedes the ability of resveratrol to deliver its benefits."   New Resveratrol and NAD+ Suggestions

"NAD+ levels markedly decline with age.11-14 NAD+ deficit manifests clinically in the form of degenerative disorders of the brain,20-23 heart,24-26 and other tissues. In animal studies, regenerative effects have been observed in the brain when NAD+ is restored. Sleep quality deteriorates with normal aging in many people. Restoring youthful NAD+ levels in the brain may support a healthy circadian rhythm. Loss of NAD+ activity is linked to type II diabetes. In mice, administration of an NAD+ precursor restores insulin sensitivity and protects against the diabetic impact of a high-fat diet."   New Resveratrol and NAD+ Suggestions

"Combining resveratrol with more nicotinamide riboside supports healthy cellular NAD+ levels,73 which are important to support anti-aging enzymes like  ... "   New Resveratrol and NAD+ Suggestions

"Aging consists of seven categories of things that happen to your cells. No. 1: Changes to DNA, including epigenetic modification and telomere length. ... Resveratrol and pterostilbene score in every category but do especially well with metabolic pathways and DNA and protein repair. ... NAD (in the form of nicotinamide riboside) is a multi-tasker that is essential in activating the sirtuin pathways and is also vital in DNA repair. "   Dr. Sandra Kaufmann The Science of Slowing Aging

“NAD+ is the term used in the scientific literature to describe a cellular compound called nicotinamide adenine dinucleotide. NAD+ is found in every cell in the body and is essential to life.1,2 NAD+ enables the transfer of energy from the foods we eat to vital cell functions. It is also required to “turn off” genes that accelerate degenerative aging processes.3,4 As NAD+ levels decline, mitochondrial function is impaired, resulting in fewer mitochondria surviving.3,5 This vicious cycle of mitochondrial depletion results in many of the physical symptoms of aging. The challenge we at Life Extension have faced over the past 13 years is finding an efficient way for aging humans to affordably boost their NAD+ cellular levels.”   The Youth Restoring Benefits Of NAD+

“By increasing intracellular NAD+ levels, age-related mitochondrial dysfunction can be reversed.5 One of the ways to accomplish this is by engaging in major calorie restriction, which has been proven to raise NAD+ levels and in experimental organisms tested to date, to extend life span.5,25 But most people find significant calorie restriction to be nearly impossible in practice. Fortunately, a method has been developed to increase NAD+ levels without having to alter dietary patterns, though Life Extension remains a strong advocate of calorie restriction for those able to consistently do it. “   The Youth Restoring Benefits Of NAD+   Note fasting even for a meal or day will help regenerate your mitochondria

“Restoring NAD+ by supplementing NAD+ intermediates can dramatically ameliorate these age-associated functional defects, counteracting many diseases of aging, including neurodegenerative diseases. Thus, the combination of sirtuin activation and NAD+ intermediate supplementation may be an effective anti-aging intervention, providing hope to aging societies worldwide.” 10    The Youth Restoring Benefits Of NAD+

"Encouraging new findings about NAD+, however, offer new hope for prevention of Alzheimer’s, highlighting the NAD+ precursor’s multitargeted actions. This latest study shows that NAD+ restoration improves cognitive function of mice with early Alzheimer’s. Boosting NAD+ enables a wide range of cellular events, including improved DNA repair and a reduction in toxic pTau proteins. A number of previous studies document the effectiveness of boosting NAD+ in protecting brain functions and improving cognition."   Nicotinamide Riboside

"A form of vitamin B3, nicotinamide riboside helps reverse the decline of NAD+ due to aging.7, 8 NAD+ is a coenzyme that plays an essential role in maintaining cellular metabolism: Higher cellular levels of NAD+ can enhance mitochondrial efficiency, which may improve your energy levels and overall physical performance. NAD+ also plays a role in healthy brain function."   Uncovering the Not-So-Secret Secrets of Longevity and Overall Wellness

"The likely involvement of the kinase pathway is implicated in the unique effects of nicotinamide riboside in raising tissue NAD concentrations in rodents and for potent effects in eliciting insulin sensitivity, mitochondrial biogenesis, and enhancement of sirtuin functions. Additional studies with nicotinamide riboside in models of Alzheimer's disease indicate bioavailability to brain and protective effects, likely by stimulation of brain NAD synthesis."   Nicotinamide riboside, a trace nutrient in foods, is a vitamin B3 with effects on energy metabolism and neuroprotection

Resveratrol (Grapeseed Extract) favorably affects your DNA, Sirtuin, Epigenetic and related mechanisms. This complex process is proven to extend your HEALTHSPAN and give you decades of additional GOOD YEARS.

NAD+ is an important player in this complex and terribly important process. Without NAD+ your Sirtuins have a hard time extending your healthspan. NAD+ also plays many other roles in extending your healthspan. It will take you a little time to sort through this somewhat complex and ,foreign to most of us, process. BUT if you are 50 or over IMO it is very important you understand the big picture and ACT on your knowledge.

     

DNA, Sirtuins, NAD+ and Old Age

"When you are young, you have less DNA damage, so the DNA repair mechanisms are less active. As you get older, you have more DNA damage and less capacity to fix it, so that category becomes extraordinarily important."   Dr. Sandra Kaufmann The Science of Slowing Aging

"Aging consists of seven categories of things that happen to your cells. No. 1: Changes to DNA, including epigenetic modification and telomere length. ... Resveratrol and pterostilbene score in every category but do especially well with metabolic pathways and DNA and protein repair. ... NAD (in the form of nicotinamide riboside) is a multi-tasker that is essential in activating the sirtuin pathways and is also vital in DNA repair. "   Dr. Sandra Kaufmann The Science of Slowing Aging

"Sirtuin activators that are hundreds of times more powerful than resveratrol increase insulin sensitivity, and have therefore been proposed as a treatment for type II diabetes.21 Powerful sirtuin-activators have also been shown to improve the general health and lifespan of mice fed a normal diet.22 Sirtuins can rejuvenate cells by stimulating the recycling of damaged cellular components (autophagy). Sirtuins require the substance NAD+ to function. Sirtuins are important for DNA repair and for efficient function of the energy-producing cellular organelles, mitochondria."   Sirtuins and NAD+ for Rejuvenation

"NAD+ declines with age because an enzyme in inflammatory cells that destroys NAD+ increases with age.25 Reducing inflammation, inhibiting the inflammatory enzyme, and replacing NAD+ by supplementing with substances (such as nicotinamide riboside) that lead to NAD+ formation, can restore the benefits of sirtuin and NAD+ (improved insulin sensitivity, mitochondrial function, and DNA repair).25 Moreover, NAD+ restoration rejuvenates stem cells, improving the regenerative capacity of organs and tissues."   Sirtuins and NAD+ for Rejuvenation

As we age our protection and nutrition of our DNA becomes more and more important. It will pay you to learn how to do this increasingly important task. One fun fact emerges our old friend EXERCISE and its partner in the mists of time FASTING are very important to your DNA continuing to keep you going in fine form. While you are studying your DNA be sure to understand how your epigenome modifies the expression of your DNA on the way to constructing your body.

Exercise and fasting increase your healthspan by increasing your Sirtuins. To do this job Sirtuins require NAD+; so you MUST help supply this NAD+, which normally declines drastically with age. By age 70 - 80 or so you will normally have almost NO NAD+. Unless you look after your NAD+ you will have little chance of taking that 200 mile hike with a full pack. This is unacceptable to me so I WORK on this important task of healthy aging.

     

Sirtuins and NAD+ for Cellar Rejuvenation

"Sirtuin activators that are hundreds of times more powerful than resveratrol increase insulin sensitivity, and have therefore been proposed as a treatment for type II diabetes.21 Powerful sirtuin-activators have also been shown to improve the general health and lifespan of mice fed a normal diet.22 Sirtuins can rejuvenate cells by stimulating the recycling of damaged cellular components (autophagy). Sirtuins require the substance NAD+ to function. Sirtuins are important for DNA repair and for efficient function of the energy-producing cellular organelles, mitochondria."   Sirtuins and NAD+ for Rejuvenation

"The most effective way to boost NAD+ levels in the body is through a newly discovered form of vitamin B3 called nicotinamide riboside.10 Studies have shown that nicotinamide riboside switches “off” the genes of aging, extends life span, increases endurance, improves cognitive function, activates beneficial sirtuins, and enhances cellular energy.5,11 "   Nicotinamide Riboside Boosts NAD+

"NAD+ declines with age because an enzyme in inflammatory cells that destroys NAD+ increases with age.25 Reducing inflammation, inhibiting the inflammatory enzyme, and replacing NAD+ by supplementing with substances (such as nicotinamide riboside) that lead to NAD+ formation, can restore the benefits of sirtuin and NAD+ (improved insulin sensitivity, mitochondrial function, and DNA repair).25 Moreover, NAD+ restoration rejuvenates stem cells, improving the regenerative capacity of organs and tissues."   Sirtuins and NAD+ for Rejuvenation

NAD+ is REQUIRED to unlock the MANY Sirtuin benefits; please assure your NAD+; not an easy task.

Sirtuins, stem cells, apoptosis, autophagy and the whole cellular rejuvenation process should interest you; it is fascinating if nothing else. I believe there are a few decades of good life in this knowledge.

Above you can see how NAD+ can improve your very important apoptosis and autophagy process and how this can help improve your healthspan.

How to Boost Sirtuins

IMO make it a priority to get the Healthspan elongating Sirtuins WORKING to LENGTHEN your HEALTHY old age and your HEALTH at any age. At eighty I can tell you getting old is not so bad as long as you CAN DO most everything you want to do.

     

NAD+ Benefits

"For resveratrol users, NAD+ is especially important. That’s because resveratrol promotes expression of cell proteins called sirtuins that protect against age-related decline. But sirtuins need NAD+ to function. And as we age, NAD+ levels drastically plummet. The result is loss of cellular functions and potential accelerated aging. A patented supplement called nicotinamide riboside replenishes cellular NAD+. Studies reveal how restoring NAD+ may slow or halt certain aging processes, boost brain function, and reduce risk for age-related disorders."   Power a Longer Life via NAD+ Restoration

  • Longevity, Sirtuin Enabling

  • DNA Repair

  • Brain Health

  • Heart Health

  • Liver Health

  • Telomere Benefits

  • Reduced Blood Vessel Inflammation

  • Insulin Enhancement

  • Muscle Enhancement

  • Energy Production

  • Immune Benefits

  • Chromosome Stability

    

Autophagy and NAD+

"Sirtuin activators that are hundreds of times more powerful than resveratrol increase insulin sensitivity, and have therefore been proposed as a treatment for type II diabetes.21 Powerful sirtuin-activators have also been shown to improve the general health and lifespan of mice fed a normal diet.22 Sirtuins can rejuvenate cells by stimulating the recycling of damaged cellular components (autophagy). Sirtuins require the substance NAD+ to function. Sirtuins are important for DNA repair and for efficient function of the energy-producing cellular organelles, mitochondria."   Sirtuins and NAD+ for Rejuvenation

"There are natural methods to improve autophagy that include supplementation with lithium and NAD+ precursors like nicotinamide riboside. One of the safest and most effective methods to optimize autophagy is by activating an enzyme in our cells called AMPK. When AMPK is activated, it signals cells to remove internal pollutants via the process of autophagy. This enables cells to function in a more youthful manner, as evidenced by reduced abdominal fat stores in many people using AMPK-activating compounds."   Reverse Underlying Cause of Degenerative Aging

Sometimes a cell has a minor flaw and can be saved if the flaw can be removed, autophagy is one way to remove this flaw. Autophagy removes slightly damaged organelles and damaged proteins; recycling them if possible. This allows the cell to function as well as a younger cell. Your cells being damaged or encumbered with poorly functioning components is an important part of GROWING OLDER.

Above you can see how NAD+ can improve your very important autophagy process.

     

Brain Health and NAD+

"NAD+ levels markedly decline with age.11-14 NAD+ deficit manifests clinically in the form of degenerative disorders of the brain,20-23 heart,24-26 and other tissues. In animal studies, regenerative effects have been observed in the brain when NAD+ is restored. Sleep quality deteriorates with normal aging in many people. Restoring youthful NAD+ levels in the brain may support a healthy circadian rhythm. Loss of NAD+ activity is linked to type II diabetes. In mice, administration of an NAD+ precursor restores insulin sensitivity and protects against the diabetic impact of a high-fat diet."   New Resveratrol and NAD+ Suggestions

"A form of vitamin B3, nicotinamide riboside helps reverse the decline of NAD+ due to aging.7, 8 NAD+ is a coenzyme that plays an essential role in maintaining cellular metabolism: Higher cellular levels of NAD+ can enhance mitochondrial efficiency, which may improve your energy levels and overall physical performance. NAD+ also plays a role in healthy brain function."   Uncovering the Not-So-Secret Secrets of Longevity and Overall Wellness

"Encouraging new findings about NAD+, however, offer new hope for prevention of Alzheimer’s, highlighting the NAD+ precursor’s multitargeted actions. This latest study shows that NAD+ restoration improves cognitive function of mice with early Alzheimer’s. Boosting NAD+ enables a wide range of cellular events, including improved DNA repair and a reduction in toxic pTau proteins. A number of previous studies document the effectiveness of boosting NAD+ in protecting brain functions and improving cognition."   Nicotinamide Riboside

"For resveratrol users, NAD+ is especially important. That’s because resveratrol promotes expression of cell proteins called sirtuins that protect against age-related decline. But sirtuins need NAD+ to function. And as we age, NAD+ levels drastically plummet. The result is loss of cellular functions and potential accelerated aging. A patented supplement called nicotinamide riboside replenishes cellular NAD+. Studies reveal how restoring NAD+ may slow or halt certain aging processes, boost brain function, and reduce risk for age-related disorders."   Power a Longer Life via NAD+ Restoration

Restoring your NAD+ in our middle to older ages can have an important impact on thinking clearly as we age. Not to mention avoiding Alzheimer's and Parkinson's.

      

Muscle Growth and NAD+

"A study published in the journal Cell Metabolism found potential benefit for supplementation with the NAD precursor nicotinamide riboside in muscle maintenance. NAD (nicotinamide adenine dinucleotide) is a compound made in the body that supports the mitochondria which serve as cells’ power plants, but it declines with age. The University of Pennsylvania’s Joseph Baur, PhD, and colleagues genetically modified mice so the amount of NAD could be restricted to mimic normal aging. While the mice initially tolerated an 85% decline in intramuscular NAD without loss of spontaneous activity or exercise endurance, they began to experience weakness and muscle-fiber atrophy in early adulthood. But giving the mice nicotinamide riboside resulted in complete reversal of muscle decline."   Nicotinamide Riboside Supplementation Restores Lost Muscles

"Encouraging new findings about NAD+, however, offer new hope for prevention of Alzheimer’s, highlighting the NAD+ precursor’s multitargeted actions. This latest study shows that NAD+ restoration improves cognitive function of mice with early Alzheimer’s. Boosting NAD+ enables a wide range of cellular events, including improved DNA repair and a reduction in toxic pTau proteins. A number of previous studies document the effectiveness of boosting NAD+ in protecting brain functions and improving cognition."   Nicotinamide Riboside

"A form of vitamin B3, nicotinamide riboside helps reverse the decline of NAD+ due to aging.7, 8 NAD+ is a coenzyme that plays an essential role in maintaining cellular metabolism: Higher cellular levels of NAD+ can enhance mitochondrial efficiency, which may improve your energy levels and overall physical performance. NAD+ also plays a role in healthy brain function."   Uncovering the Not-So-Secret Secrets of Longevity and Overall Wellness

     

Foods That Will Naturally Increase NAD+

"This [Yeast] is one of the most essential components in making bread and cakes. Yeast makes the dough rise. Interestingly, it contains Nicotinamide Riboside (NR). This is the precursor to NAD+. Hence, consuming pastries which have some yeast in it can contribute to growing younger. As a matter of fact, yeast actually contains more NAD+ per part than milk."    7 Foods That Will Naturally Increase NAD+   Note this would imply Nutritional Yeast may be a good NAD+ source

However

"On a per calorie basis, foods will unfortunately be a very poor source. Even if you consumed vast amounts in one serving, you may not even get a 1 mg of NR. The solution isn’t consuming niacin rich foods, either. Why? Because all of the highest sources you buy at the grocery store are fortified – not natural – sources. Cereals, breads, and other B3 rich foods fortify with synthetic niacin, which is 100% niacin and should not have  nicotinamide riboside in it. Furthermore, you can overdose on the synthetic form of B3 and experience bad side effects as a result. Natural B3 rich foods aren’t the solution either, because on a per calorie basis yeast will have about 400% more than the next highest foods… mushrooms (white, portabella, crimini, maitake all have about the same natural niacin content). Since yeast is likely less than 1 mg, you will probably be getting 1/4 of that (at best) from mushrooms and other natural food sources. Ultimately if you want to get the amounts you hear about in the NAD+ boosting studies, you will need to buy the supplements, since diet is unfortunately not a way to obtain any significant amount. Most supplements on the market have a hundred or more milligrams per dose."    Best Nicotinamide Riboside Food Sources

Conclusion on Foods for NAD+

Looks like you NEED to supplement. Although I am taking the very salubrious Nutritional Yeast in any case, in addition.

    

On Dosing Nicotinamide Riboside

250 mg/day may be too much for you. If so try cutting the daily dose. 50 mg/day IMO is worth taking.

     

How to Increase your NAD+

"Resveratrol favorably enhances the activation of cellular sirtuin proteins.8 NAD+ is required for our sirtuins to function. As we age, NAD+ levels plummet, which impedes the ability of resveratrol to deliver its benefits."   New Resveratrol and NAD+ Suggestions

"Combining resveratrol with more nicotinamide riboside supports healthy cellular NAD+ levels,73 which are important to support anti-aging enzymes like  ... "   New Resveratrol and NAD+ Suggestions

I take a little liberty here but since all these are very salubrious and involved in the relevant processes and NAD+ is so important, I feel I am justified.

 

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This File was last updated on 26 February 2019 02:57 PM

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